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Furthermore, the autophagy enhancer rapamycin inhibits the mTOR pathway, upregulates the expression of LC3- and Beclin-1, triggers autophagy, facilitates the aggregation of PMF, and improves the survival rate of oocytes (Sun et al., 2018)

3.2), contribute to neuroprotective signaling, which include improved mitochondrial function, increased BDNF expression, and activation of anti-inflammatory signaling via GPR41/43 and HDAC inhibition [144]

(ii) Gametes and embryos from patients with endometriosis are exposed to an ROS-rich pro-oxidant microenvironment in the fallopian tubes, the ovary, and the follicle

In Neglected Tropical Diseases (eds Swinney, D., Pollastri, M., Mannhold, R., Buschmann, H