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Despite lower systemic absorption, it maintains local activity in the gut , offering significant benefits for: Ulcers and acid damage Leaky gut and intestinal inflammation NSAID-induced GI injury Key features: Shorter systemic half-life (~24 hours) Strong local effect on gastric mucosa Best used for digestive repair and mucosal protection Which Clears Faster

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The clinical translation of these trial results, which will be important for the comparison of GLP-1RAs with SGLT2 inhibitors in the treatment of patients with heart failure and a preserved ejection fraction, remains to be determined