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According to Ames and Wakimoto (132), PLP has been suggested to impact carcinogenesis via a variety of mechanisms, including those involving DNA metabolism

Reduced Systemic Exposure: Less compound circulating in the body means fewer peripheral side effects to confound CNS-specific data

Commenters shared their ideas on how to refine the complexity adjustment criteria and methodology, on the mechanics of how complexity adjustments are evaluated, and how the data is presented to the public