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Vitamin B12 supplements (not clear if this refers to physiological or pharmacological doses) lower the blood levels of homocysteine in the blood, which may be linked to increased risk of stroke or heart attacks, although the relation between vitamin B12 supplementing and lower rates of heart attacks has not been confirmed

Glutathione has many beneficial functions such as reducing oxidative stress and protecting cells from free radicals

It has powerful antioxidant, anti-inflammatory, immunomodulatory, and antitumor properties.55 In vivo and in vitro studies have shown that it can attenuate the deleterious effects of UV radiation and increase the antioxidant capacity of the skin.55 In our review of the literature, we found no clinical studies analyzing its effect on skin aging

In research models, it's shown impressive regenerative effects: But and this is important most of this data comes from animal studies or anecdotal human use, not large-scale clinical trials