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The typical treatment protocol for Mounjaro involves: Starting with a 2.5 mg dose, administered once weekly for four weeks Increasing to 5 mg weekly for the next four weeks If additional glycemic control is needed, practitioners may gradually increase the dose by 2.5 mg (to 7.5 mg , 10 mg , or 12.5 mg ) The maximum recommended dose is 15 mg This titration phase is essential for minimizing gastrointestinal reactions , such as nausea or diarrhea