levothyroxine and tirzepatide Mounjaro Increase in TSH on Zepbound

Common Gastrointestinal Concerns Both dual and triple agonists share a class-wide side effect profile dominated by gastrointestinal issues, primarily: Nausea Diarrhea or Constipation Vomiting These effects are dose-related and typically peak during the dose-escalation phase

Scientists are increasingly interested in understanding how multiple hormonal systems work together rather than focusing on a single biological pathway

Improved insulin sensitivity allows the body to more effectively utilize stored fat for energy rather than promoting continued fat accumulation

Patients considering this route should understand the tradeoffs