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More recently, others have found elevated expression of the NAD + glycohydrolase enzyme CD38 in the ovary during reproductive ageing, and showed that blocking the degradation of NAD + through small molecule inhibition of CD38 can prolong female reproductive lifespan (Perrone et al, 2023

If the machinery behind that process is already compromised, dirty genes, underperforming enzymes, insufficient cofactors, an overloaded liver, the backlog gets worse

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The growing size of the literature highlighting the impact of research methodologies on quantification of blood-based biological analytes further supports the need for standardized research techniques when it comes to blood-based biomarker collection, preparation, and storage