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C9orf72 protein can be recognized by T cells as an autoantigen, and this ALS-associated T cell autoreactivity was found broadly in ALS patients, though it was particularly high in C9orf72 mutation carriers (Michaelis et al., 2025)

doi: 10.1017/S0033291702006815 59 KlumpKLRacineSEHildebrandtBAlexandra BurtSNealeMSiskCLet al