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National Institute of Diabetes and Digestive and Kidney Diseases

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Randomization was conducted using an interactive web response system, assigning participants in a 6:1 ratio to one of several treatment arms: once-weekly subcutaneous Cagrilintide administered in doses of 0.3, 0.6, 1.2, 2.4, or 4.5 mg, once-daily liraglutide 3.0 mg, or a volume-matched placebo

This guide covers the complete retatrutide dosage escalation schedule, dose-by-dose weight loss outcomes, safety profiles by dose level, and reconstitution protocols for research use