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While numerous randomized clinical trials substantiate the antidepressant efficacy of Rhodiola, Ginkgo, and Ashwagandha, these investigations are frequently hindered by limited sample sizes, diverse dosing protocols, variability in extract standardization, and insufficient integration of mechanistic biomarkers

Schilling, C

Upregulates genes involved in antioxidant defense (superoxide dismutase, catalase), tissue repair (collagen synthesis, matrix metalloproteinases), anti-inflammation (suppressing TNF-, IL-6)

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