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Owing to the origin of the raw materials, the medicinal components, the growth years of the medicinal materials, and the extraction technique, the purity, composition (e.g., polysaccharide content), and chemical structure of APS will vary (Zheng et al., 2020)

Among these, melatonin emerges as a central integrative signal linking circadian timing, sleep regulation, nutritional cues, and antioxidant defense, particularly in the context of aging (Su et al., 2025)

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A promising avenue involves the utilization of cysteine-rich protein-based tactics targeting cysteine-rich angiogenic inducer 61 (CCN1/CYR61) (123), which could potentially mitigate the biological aggressiveness of TNBC or BLBC