danuglipron and lotiglipron were discontinued in development due to hepatotoxicity signals, underscoring safety considerations unique to this drug class
Common side effects: Gastrointestinal issues: Patients may experience nausea, vomiting, diarrhea, constipation, abdominal pain, and indigestion General discomfort: Fatigue, hair loss, and dizziness are also reported, along with reactions at the injection site such as bruising, itching, and skin rashes Mild allergic reactions: Some individuals may encounter bloating, gas, burping, and mild allergic reactions Serious side effects: Digestive system: Severe digestive side effects, including acute kidney injury and gallbladder disease can occur Pancreatitis: There is a risk of acute pancreatitis, a serious inflammation of the pancreas Endocrine concerns: Low blood sugar levels, especially when used with other medications that lower blood sugar, and risk of thyroid cancer are significant concerns Mental health: Depression and suicidal thoughts or behaviors are serious side effects that require immediate medical attention Allergic reactions: Severe allergic reactions may manifest as skin rashes, itchiness, and swelling FDA boxed warning and precautions: Thyroid cancer: Zepbound comes with an FDA-boxed warning for the risk of thyroid cancer, the most stringent warning by the agency Contraindications: It may not be suitable for individuals with certain health conditions, or for those who are pregnant or breastfeeding Interactions: Zepbound can interact with several medications, including birth control pills, insulins, sulfonylureas, and warfarin, potentially diminishing their effectiveness or causing additional side effects Patients are advised to discuss any symptoms of thyroid cancer and kidney problems with their healthcare provider
Lyophilized BPC-157 should be stored at 20C
Glutathione has many important functions in the body, but it is most well-known for its role as a strong antioxidant
