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Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle

So, for example, during expression and purification of a recombinant protein, it may have a disulfide bond form, which wouldnt normally form in the proteins natural context

First, glutamate-cysteine ligase (GCL) links glutamate and cysteine to form -glutamyl cysteine (rate-limiting steps)

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