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BACs, while technically challenging to prepare, are particularly well-suited for expression of BGCs anchored by large, multimodular PKSs, as illustrated by the following examples (Figure 26): i) heterologous expression of quinolidomicin A 1 ( 122 ), which is a 60-membered macrocyclic compound from Micromonospora sp., in S

This interaction site is less defined but comprises the glutathione moiety of Grx(SSG), parts of helix 3, and a conserved lysine/arginine residue that also contributes to the scaffold site 14,15

Typically, circulating Fe 3+ in the blood is absorbed mainly through the mediation of transferrin receptor 1 (TFR1) and binding with transferrin