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The 3.0 mL dilution is deliberately large so low microgram doses read on clear U-100 markings

The analysis tested the PCSK9 inhibitor evolocumab in patients with high-risk type 2 diabetes defined by microvascular disease, insulin use, or a diabetes duration of at least ten years who had not yet experienced a heart attack or stroke

Pre-Blend Reconstitution Math (12.5/2.5 mg, 15 mg total) Metric Blend composition Value 12.5 mg retatrutide + 2.5 mg cagrilintide Metric BAC water added Value 2.5 mL Metric Concentration Value 5.0 mg/mL retatrutide + 1.0 mg/mL cagrilintide Metric Ratio held constant Value 5:1 (reta : cag) What Each Draw Delivers (12.5/2.5 mg Pre-Blend) Draw Volume 0.20 mL Units 20 units Retatrutide 1.0 mg Cagrilintide 0.2 mg Draw Volume 0.40 mL Units 40 units Retatrutide 2.0 mg Cagrilintide 0.4 mg Draw Volume 0.60 mL Units 60 units Retatrutide 3.0 mg Cagrilintide 0.6 mg Draw Volume 0.80 mL Units 80 units Retatrutide 4.0 mg Cagrilintide 0.8 mg Draw Volume 1.20 mL Units 120 units* Retatrutide 6.0 mg Cagrilintide 1.2 mg Draw Volume 1.60 mL Units 160 units* Retatrutide 8.0 mg Cagrilintide 1.6 mg Draw Volume 2.40 mL Units 240 units* Retatrutide 12.0 mg Cagrilintide 2.4 mg * Volumes above 100 units exceed a standard 1 mL insulin syringe - split into two injections or use a larger syringe

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