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The second pathogenic variant can be another hemoglobin S allele or other Hb variants such as HbC (HBB GLU6LYS)

Indications: resulting either from organic heart disease or from cardiac surgical procedures inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility Contraindications: Patients with idiopathic hypertrophic subaortic stenosis (IHSS) and in patients who have shown previous manifestations of hypersensitivity to dobutamine Patients with IHSS have an asymmetric septal hypertrophy resulting in a dynamic left ventricular outflow obstruction (LVOT)

cDNA was prepared using ReverTra Ace (Toyobo) according to the manufacturers instructions

My skin looks dull and dry