Autophagy 16 (8), 14531467
Critical Safety Gaps for Mental Health Applications Unknown effects on cognitive function, memory, personality, mood stability beyond intended therapeutic effect Long-term impacts on brain chemistry (chronic administration effects unexplored beyond 6 weeks in animals) Potential for psychological dependence or tolerance (not studied systematically) Impacts on developing brains in adolescents and young adults (completely unknown with no pediatric studies) Drug Interactions Pose Serious Concerns BPC-157s simultaneous effects on serotonin, dopamine, GABA, glutamate, and nitric oxide systems create multiple theoretical interaction points with psychiatric medications, yet interactions are not well studied. Specific concerns include: With SSRIs and SNRIs: Risk of serotonin syndrome is genuine
Anjan Chatterjee told me that there just arent enough studies of these drugs in normal people. He said, In the situations where they do help, do they come with a cost? As he wrote in a recent letter to Nature , Most seasoned physicians have had the sobering experience of prescribing medications that, despite good intentions, caused bad outcomes. Given that cognitive enhancement is a choice, not a necessity, the cost-benefit calculation for neuroenhancers should probably be different than it is for, say, heart medications
May 31 2022 Faria-Gonzlez et al., Journal of Intensive Care Medicine, doi:10.1177/08850666221105423 Hourly Analysis of Mechanical Ventilation Parameters in Critically Ill Adult Covid-19 Patients: Association with Mortality 39% lower mortality (p=0.08)
