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This is evident in children with obesity and asthma, where impaired glucose and insulin metabolism is associated with significantly increased AHR, both dependent and independent of BMI [44]

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For women with PCOS who struggle with irregular periods, Metformin can be a significant aid

Effects may be less dramatic than the first course if the initial burden was substantially reduced Maintenance: Some community protocols transition to once-yearly courses for ongoing senescent cell management There is no research to validate this approach