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The role of the linker is to ensure that the two different protein structural domains are correctly connected and maintain their biological activity without degradation

Predation, an essential driver of evolutionary change, becomes impossible

Once activated, the STAT family enters the nucleus and begins transcribing a very important growth factor, Insulin-like Growth Factor 1 (IGF-1), also known as Somatomedin C, which is crucial for body growth

Obviously, the ECD of the closed conformation prevents GLP-1 binding and further experiments are necessary to fully understand the functional impact of the closed ECD conformation on Gs binding