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On one hand, IBD can lead to dysregulation of adipokines, shifting the balance towards a pro-inflammatory state, on the other hand obesity and higher BMI are associated with higher risk of developing IBD and worse clinical outcomes, particularly for UC

About 26% discontinued GLP-1 therapy over three years, and another 23% had interruptions in treatment

It is worth noting that the oral formulation of semaglutide (Rybelsus) does require specific administration instructions, including taking it on an empty stomach with no more than 4 ounces of water and waiting 30 minutes before eating, drinking, or taking other oral medications