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KEYWORDS: Advertising, direct-to-consumer, compounded, GLP-1, obesity, semaglutide, tirzepatide, weight loss Background To date, the Food and Drug Administration (FDA) has approved three glucagon-like peptide-1 (GLP-1) receptor agonists as pharmacologic treatments for chronic weight management (Chen et al., 2023)

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However, despite their promising activity in pre-clinical models, HDIs have demonstrated only modest antitumour activity in initial clinical trials in solid malignancies