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A synthetic peptide, AWRK6, developed based on the antimicrobial peptide Dybowskin-2CDYa, was reported to attenuate hyperglycemia as a novel GLP-1 receptor agonist candidate

2f, g) might lead to damage of the mitochondrial membrane and/or ETC malfunction

JACC Basic Transl Sci 4:575591 Tochiya M, Makino H, Tamanaha T, Matsuo M, Hishida A, Koezuka R, Ohata Y, Tomita T, Son C, Miyamoto Y, Yasuda S, Hosoda K (2020) Effect of tofogliflozin on cardiac and vascular endothelial function in patients with type 2 diabetes and heart diseases: A pilot study

2f), with a vast increase in metabolite abundance 72 h post treatment (Fig