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Although past meta-analyses reported substantial reductions in MACE with DPP-4 inhibitors [23], their conclusions were based on studies with small sample sizes and limited numbers of cardiovascular events, which have not been confirmed by the four CVOTs specifically designed to assess the CV safety of DPP-4 inhibitors

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#5 Prozac and Over-the-Counter Painkillers In addition to the adverse effects that can be expected with prescription opioids, over-the-counter painkillers may also react negatively with Prozac

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