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Advantage: Potential for higher bioavailability than standard oral ingestion Challenge: Peptides are poorly absorbed through intact mucosal membranes without transport mechanisms Evidence: No studies confirm enhanced sublingual bioavailability for Dihexa Standard oral (swallowed): Tablets swallowed with water, absorbed through the gastrointestinal tract

Nephrons also put good stuff, like nutrients, back into the bloodstream

For CY 2024 we continued to define immediate availability as including real-time audio and visual interactive telecommunications through December 31, 2024, and solicited comment on whether we should consider extending the definition of direct supervision to permit virtual presence beyond December 31, 2024

Bookshelf ID: NBK442376 130 MeekerJDFergusonKK