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After each 3-month cycle, you go through a reassessment to determine whether to continue, adjust doses, or change medications

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and Nrf2/heme oxygenase-1 (HO-1) [60, 62,63,64]

Metabolism & Elimination The metabolic fate and degradation pathways of MOTS-c remain incompletely characterized, representing a significant gap in pharmacokinetic understanding: Rapid plasma clearance observed in preclinical models, though precise half-life not definitively established Likely degradation through peptidase activity, though specific enzymes not identified No accumulation detected in chronic administration studies (animal models) Active metabolites not characterized