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Providers typically begin with lower doses to help reduce gastrointestinal side effects and improve overall tolerability

Introduction Retatrutide (development code LY3437943) is an investigational single-molecule agonist reported to engage three incretin- and metabolism-related receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR)

It is prescribed to help control blood sugar levels in adults with type 2 diabetes, often in combination with diet and exercise

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