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In pulmonary arterial hypertension (PAH), specific studies using monocrotaline (MCT)-induced PAH models suggest that liraglutide acts through the NO/sGC/cGMP pathway, increasing NO release, activating soluble guanylate cyclase (sGC), and enhancing cyclic guanosine monophosphate (cGMP) synthesis

The starting dose is 1.5mg, gradually increasing to 4mg, 9mg and 25mg, with patients required to remain on each dose level for at least a month before progressing

Dehydration worsens constipation (already a common semaglutide side effect), increases fatigue, and can mimic hunger when you are actually just thirsty