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First, start berberine at a low dose (typically 500 mg once or twice daily) and titrate slowly over 2-3 weeks while monitoring blood sugar, energy levels, and gastrointestinal symptoms

c , Heart weights of mice in Extended Data Figs

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A discussion of the use of carglumic acid in its other approved indication (hyperammonaemia due to primary NAG synthase deficiency) is beyond the scope of this article