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An increase in the renal production of ammonia could be another factor that contributes to the development of hyperammonaemia in VPA-treated patients

The sponsors had no role in the design and conduct of the study

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Regulatory Investigations In July 2023, the Icelandic Medicines Agency received reports about suicidal ideation in patients using GLP-1s, and the European Medicines Agency (EMA) initiated a review of a possible association between GLP-1 usage and suicidal ideation