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In a randomized placebo-controlled, double-blinded trial, although liraglutide did not affect A load and cognition measures, 26 weeks of liraglutide treatment prevented expected decline of glucose metabolism that signifies cognitive impairment, synaptic dysfunction, and disease evolution (243)
Surprisingly, Gclc KO mice showed no signs of liver damage, both by histology and serum biochemistry markers (Fig
This is the scientific rationale for combination pharmacotherapy
