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Moreover, TMAO increased the expression and activity of tissue factor (TF) via activation of the NF-B signaling pathway in primary human coronary artery endothelial cells (HCAECs), thereby promoting atherothrombosis (Cheng et al., 2019)

GIP also induces osteopontin expression in adipocytes (65), an adipokine associated with obesity-related systemic low grade inflammation (66, 67)

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