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However, most previous studies have focused on alcohol, and few have examined whether these medications might also help people who already have a substance use disorder

Sources Lilly - What to know about retatrutide (updated March 2026) Lilly - TRIUMPH-4 Phase 3 retatrutide results on weight loss (December 11, 2025) Lilly - TRANSCEND-T2D-1 Phase 3 retatrutide results in type 2 diabetes (March 19, 2026) Lilly - TRIUMPH Phase 3 trial listing Jastreboff AM et al

If you're considering microdosing, work closely with a healthcare provider, use legitimate medications when possible, and set realistic expectations

L.CastelaoE.RothenS.GlausJ.VollenweiderP.et al