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i, j) daLUXendin544 labelling is reduced in GLP1R KO/KO islets, and further reduced in GLP1R KO/KO islets + 1 M GIP Aib2 (n = 37 islets from 2 mice) (Kruskal-Walllis test with two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli)

The depletion of this antioxidant has been correlated with lower immune function and increased vulnerability to infection due to the liver's reduced ability to detoxify

While animal studies show a good safety profile, a theoretical risk involving its pro-angiogenic effects and potential cancer promotion is a point of consideration, though no evidence has supported this risk in practice

Similarly, the SwedeHF study, comprising 4942 patients, found that female sex, nonischemic causes, higher blood pressure, and shorter heart failure duration were predictors of HFimpEF 24