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[27] Opioid-induced constipation Clinical features Recent initiation of an opioid or dose adjustment New or worsening constipation Fecal impaction may be present Physical examination typically normal Diagnostics [8] Clinical diagnosis Rome IV diagnostic criteria for OIC Recent initiation of opioid treatment or a dose increase AND 2 of the characteristic clinical features of functional constipation: Passage of spontaneous bowel movement 20% of the markers are retained