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[21] Individual factors that may increase susceptibility to fish oil-related diarrhoea include: Pre-existing digestive conditions (irritable bowel syndrome, inflammatory bowel disease, malabsorption disorders) Reduced bile acid production or gallbladder dysfunction Pancreatic insufficiency affecting fat digestion Taking supplements on an empty stomach Rapid dose escalation without gradual introduction Poor-quality supplements with potential oxidation If you have a diagnosed fat malabsorption condition, gallbladder disease or pancreatic insufficiency, seek medical advice before taking fish oil supplements

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