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Combination use has been explored in clinical studies, including double blind placebo controlled and placebo controlled evaluation models involving healthy male subjects, healthy males, and diabetic men, showing clinically significant changes in sexual arousal, sexual desire, and sexual performance without compromising blood pressure when properly monitored

Nature 426 , 787 (2003)

These findings enrich our understanding of the structural biology of the ghrelin receptor, particularly its ligand recognition and activation mechanisms