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Antioxidants 12(5):1075 Adilakshmi P, Suganthi V, Rao KS, Mahendran KB (2023) Effect of high-intensity resistance training versus endurance training on irisin and adipomyokine levels in healthy individuals: an 8-week interventional study

From there, they may gradually increase your dose over time (depending on how well you tolerate the medication) until you reach a maintenance dose for weight loss