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There is a small chance of allergy or irritation, but this is rare with correct use

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We can get a sense of this if we look at the death-response curve: As Campbell and Dunaif noted, The total dose for the highest dose group (4.0 mg/kg) approaches the median lethal dose of 5.0 mg/kg for male F344 rats. The median lethal dose, or LD 50 , is the dose required to kill half the animals