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Apigenin increased production of cleaved caspase-3, cleaved caspase-8, and cleaved PARP, which inhibited the proliferation and colony formation of HER2+ BT-474 cells (160)

In vivo , the invasive-growth programming from c-MET/HGF signalling is thought to be an integrated function of a variety of biological responses such as cell proliferation and survival, cell dissociation/scattering, motility, induction of cell polarity, angiogenesis, wound healing, tissue regeneration, invasion, and tumour metastasis (Stella and Comoglio, 1999

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