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Replacing the sulfonic acid at position R 1 with a sulfonamide group ( 33 ) resulted in a drastic decrease in solubility of the fragment with a concomitant reduction of binding to TRF1 TRFH by CPMG, whilst the dimethyl sulfonamide 35 or the even bigger benzyl sulfonamide 36 showed an even poorer solubility and a loss of TRF1 TRFH binding (Table 1)

TB-500: 43 amino acids (Thymosin Beta-4 fragment), derived from thymus protein, primary mechanism is actin polymerization and cell migration, most studied for wound healing and cardiac repair

TB-500 provides the cellular scaffolding and migration pathway

doi: 10.1210/en.2014-1685 [DOI] [PubMed] [Google Scholar] 74.Roman-Prez M, Outeirio-Iglesias V, Gil-Lozano M, Gonzlez-Matas LC, Mallo F, Vigo E