On tolerability, both compounds produced mild-to-moderate gastrointestinal adverse events (nausea, diarrhea, constipation, vomiting), typically during dose escalation
Artemisinin and its derivatives can reduce DNA damage, oxidative stress, and inflammation, inhibit cell proliferation, promote apoptosis, and regulate the cell cycle through multiple pathways, such as the TLR/NF-B, Keap1/Nrf2, and PI3K/Akt signaling pathways, thereby exerting a therapeutic effect on lung cancer and pre-lung cancer diseases
Semaglutide (Wegovy) for the treatment of obesity or weight management should not be used during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm due to the potential hazard of maternal weight loss to the fetus
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