2.2 The role of inflammation in endometriosis The coordinated action of macrophages, endometrial cells, endothelial cells, and activated lymphocytes, along with cytokines and chemokines, alters the abdominal immune microenvironment, facilitating pathological processes including cell proliferation, angiogenesis, lesion adhesion, growth, and invasion (34)
This constraint has material implications for CIP strategy
Why refrigeration helps after opening: Slows oxidation (copper can oxidize) Prevents bacterial contamination Maintains potency longer Extends usable life Room temperature storage after opening: Acceptable for 3-6 months if product has strong preservatives Use quickly if stored at room temp Watch for signs of degradation Refrigerated storage after opening: Extends life to 6-12 months Better potency retention Reduced oxidation Signs your topical copper peptide has degraded: Color change (darker, more blue/green) Separation of layers Change in texture Reduced effectiveness Unusual smell Application tip: If refrigerated, let serum warm to room temperature before applying
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