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Melanonychia tends to persist, except when it is related to medication in which case it fades following its withdrawal.

however, no G6PD deficiency has been reported in this unique situation because all affected patients are heterozygotes and presumably in the blood there is overwhelming selection in favor of the cells in which the active X chromosome has the normal Gd allele

The copper is what enables the biological activity GHK without copper has significantly reduced effect on gene expression and tissue repair