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Metformin) with diagnosis of type 2 diabetes Documented history of lifestyle intervention Quarterly clinical review to assess improvement (weight loss or A1C) Discontinuation if there is no measurable improvement after 6 months 3

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Additionally, the convex paratope of heavy chain only antibodies (VHHs), including their long CDRH3, appears ideally suited to engage the orthosteric pocket of GPCRs

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