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Regional Disciplinary Medical Board: vitamin B12 cannot be overdosed In 2009, the Regional Disciplinary Medical Board in Eindhoven stated very clearly that an overdose is not possible: There can be no question of an overdose of hydroxocobalamin, as the excess is excreted in urine by the kidneys and therefore cannot accumulate in the body

These can make daily life hard, as B12 is key for energy and brain health

Theres also the possibility of insulin resistancethe bodys lowered ability to regulate blood sugarwhich comes with its own metabolic risk factors, like kidney disease and type 2 diabetes