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However, these combination therapies have not shown a significant increase in overall survival compared to chemotherapy alone [35,36,37,38]

Bowel irrigation may be accomplished by administering an isotonic solution of polyethylene glycol (i.e., GoLytely) via an orogastric tube, beginning at a rate of 1.5-2 liters/hour

Studies show that patients who titrate slowly over 8 to 12 weeks experience significantly milder gastrointestinal symptoms compared to those who rapidly increase doses

In a clinical trial, Comhaire et al [113] reported that oral intake of AXN had a positive impact on semen quality and fertility of infertile individuals