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However, no consistent inter-group differences were observed in reproductive outcomes, such as menstrual frequency or hormonal profiles, and adverse effects were primarily gastrointestinal (108)

Earlier this month, Regeneron released results from their 26 week Phase 2 COURAGE study

The first line of antioxidant defense against ROS is very efficient and is predominantly represented by the intracellular antioxidant pool, consisting of antioxidant enzymes, including Cu,Zn-SOD (SOD1), catalase, glutathione peroxidase (GPX), peroxiredoxins (PRDx)

Further, in vitro evidence (72) shows that urolithin A and its phase-II metabolites can cross the bloodbrain barrier, an ability that would be necessary for their direct effects in the brain