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Beyond pancreatic effects, GIP receptor agonism enhances peripheral insulin sensitivity, particularly in adipose tissue, where it promotes healthy white adipose tissue (WAT) expansion, facilitates dietary triglyceride clearance through increased lipoprotein lipase activity and adipose blood flow, and improves lipid buffering capacity [40]

In addition, drug repurposing, which involves investigation of existing drugs for new therapeutic purposes, particularly uses biophysics-based molecular docking approaches and has been proven to be effective and efficient and of immense value in biomedicine (184, 187)

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Effects of canagliflozin on anaemia in patients with type 2 diabetes and chronic kidney disease: a post-hoc analysis from the CREDENCE trial