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Risk of iron overload in obesity and implications in metabolic health

When lost quickly, the underlying scaffolding disappears, and the skin as well as the supporting collagen and elastin may not adapt in time, leading to sagging, deeper folds, and a deflated appearance often described as Ozempic face. Common facial changes associated with GLP-1-driven weight loss include: Sunken cheeks and temples Sagging jowls and jawline Deepening of nasolabial folds (smile lines) Downturned corners of the mouth Flattened or elongated lips Excess skin and loss of facial volume These changes result not only from fat loss but also from the skins decreased elasticity that occurs with both aging and accelerated weight reduction

Given the decades and thousands of individuals who have been on creatine, if kidney function were an issue, we should see it by now

Kirby L, Castelo-Branco G