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Description

A.FradkinJ.KernanW

This structural modification also reduces its binding affinity to IGF binding proteins, allowing it to remain bioactive in circulation significantly longer than endogenous IGF-1

All three tirzepatide doses were more effective than basal insulin both in reducing HbA 1c (mean differences ranging between 7.66 mmol/mol [0.70%] with tirzepatide 5 mg and 12.02 mmol/mol [1.09%] with tirzepatide 15 mg [ESM Fig